I've hesitated giving a review until now so as not to seem negative, but I actually like the product so much, have been using it, always hoping for the best, which leads me to this review. My hesitation was because I have tried so may fish remedies on on huge pleco, who has had a gaping open wound for over two years with no previous product working at all. I tried your remedy, have been using it, probably too much, and it has been the only product that has even remotely helped in keeping the very deep sore from getting larger, and even sometimes appears to be minimizing the size, Sometimes, there even appears to be new skin growing, and that has been the blessing for the poor guy. I've been adding the product nearly every day to the large tank, with the 2 plecos, and I have not seen any harmful side effects, just the positive one of seemingy keeping the large (horrible!) wound in check. Love the product, it appears to be with natural ingredients, and I do feel it is the only remedy that has helped, even though not cured. Really believe a cure is not in the stars for the fish, but he is still thriving. Try this product!